The truth that God is everywhere gives meaning to life in many ways. One way is that no matter where we go, we deal with our sovereign Maker. Nothing in life is totally meaningless because all that we do is in His presence. Nothing that we do is meaningless because all that we do is either for Him or against Him. Because God is fully present, everything that a person does is full of meaning. Everything a person does is out of love for God or is an act of hatred against Him and that in His presence. We could say that all that the unbeliever does is like committing a capital crime each moment since all done against God is worthy of death. We could also say that all that the believer does out of love for God is rewarded with more love for God. But both of those things can only be true if God is omnipresent.
The unbeliever is left to his or her own devices and has no real meaning in life. That is because they assume that there is no God in all the places that they are and so they are left to do as they see fit in their own strength. That means that any meaning that they find will be drawn out of the air with no substance to it at all. The unbeliever is left with nothing in this life and no hope for anything beyond. But the believer lives in the presence of God and has an ever present help in time of need. Whether the believer makes his bed in the grave or in the heavens, God is there. No matter what is happening to the believer, God is there. No matter what is going on in the believer or around the believer, God is there and He is in control. Whatever happens to the believer is not by accident, but by the sovereign permission and plan of the God who is always present. Nothing can happen to the believer that God does not allow because God is always there. This is also true of the unbeliever, but s/he does not recognize that and so lives as without God in the world.
While the unbeliever is left to his own ways and devices, the believer has the possibility of finding meaning in life in all things. No matter what the believer does and tries to the glory of God, He is there to be his or her strength in doing those things. The smallest things that are done for the glory of God are found to be from Him. The very smallest thing that a believer does out of love for God is full in its meaning. There is nothing that can happen to the believer that is a tragedy, yet the small things are full of meaning. All of that leans on the truth that God is present everywhere and is in all things.
Most people in the world, and even many professing believers, live in a world that they imagine is like Deism. Deism is the belief, generally speaking, that God made the world, set some natural laws up, and now just lets the world go along according to those laws and the free-will of the people. That is how even believers seem to think that things happen. While some think that God is present in some way, it is more like some being in the sky that is able to observe what is happening. But the Bible teaches that God is present in all places at all times. God is not just a casual observer watching all things happen from a good vantage point, He is present in all places and is aware and acting in those places. Because God is present and not just watching, this brings great meaning to the believer. The believer finds meaning in sharing the life of God in the world in being able to share in the love of God for Himself through Christ.
If God is not present in all places and at all times, then the love of God is more like some sort of objective feeling than it is of God Himself giving people a joy in Himself. If God the Father does not everywhere love God the Son through God the Holy Spirit, then His love is basically a nice thought but not a present reality. If His love within the Trinity is not present in all locations, then His love is not operational in life. If God is love, then if He is not omnipresent He is not love everywhere. But since God is everywhere and His love for Himself is present in all places, this brings a full meaning to life for believers since it means that love for God is available in all places and life is full of meaning when sharing in the love of God for God and other human beings.
Life is full of meaning because of the omnipresence of God in yet another way, though that is not something that all will enjoy. Life has meaning because there is no escape from God and there are no excuses for the way we are and the way we live. All that we do is known because He is fully present. We may try to make excuses and offer justifications for why we did certain things, but those will not work with God who is present in three Persons. All sin is witnessed by three Divine Persons and all the circumstances and reasons are weighed according to perfect reason and wisdom. But then again, so are all acts of love. It is simply beyond words to describe the meaning that the omniscience of God brings to life.
God Loves... Himself 
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